Programs
Email:kaattari@vims.edu |
Stephen L. Kaattari
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Research Interests
My laboratory currently has two foci. We have a long term interest in the basic molecular, cellular, as well as the immunochemical aspects of comparative immune system function. this knowledge is also applied to the understanding of disease resistance and pathogenesis, as well as the development of immunodiagnostcs and vaccines for aquaculture. A more recent focus id the development of monoclonal antibody probes for incorporation into real-time sensor platforms to monitor the presence and flux of pollutants, toxins, and pathogens within the estuarine environment.
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Current Projects
- The differentiation of long-lived plasma cells and plasmablasts and their role in generating humoral and classical memory
- Structure and assembly of fish antibody molecules
- Mechanisms of affinity maturation and antigen-driven selection in fish
- Mycobacteriosis in striped bass: the role of the immune response and the molecular diagnosis of the disease
- Development of real-time, antibody-based sensor platforms for the detection of pollutants and pathogens in estuarine water
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Selected Publications
Earnhart, C. G., and S. L. Kaattari. Accepted. Potential novel epitopes in the extracellular products of oyster homogenate-supplemented Perkinsus marinus cells are not detected by subtractive immunization. Journal of Parasitology.
Kaattari, S.L., E.S. Bromage, and I.M. Kaattari. Accepted. Vaccine design and the analysis of long-lived plasma cell production and regulation. Annual Review of Fish Diseases.
Bromage, E. S., I. M. Kaattari, P. Zwollo, and S. L. Kaattari. 2004. Plasmablast and plasma cell production and distribution in trout immune tissues. Journal of Immunology 173:.7317-7323.
Bromage, E. S., J. Ye, L. Owens, I. M. Kaattari, and S. L. Kaattari. 2004. Use of Staphylococcal protein A in the analysis of teleost immunoglobulin structural diversity. Developmenatl and Comparative Immunology. 28:803-814.
Earnhart, C. G., G. D. Brown, M. A. Vogelbein, K. S. Reece, and S. L. Kaattari. 2004. Supplementation of parasite cultures with host plasma or tissue homogenate enhances their infectivity. Applied and Environmental Microbiology. 70:421-431.
Kaattari, S. L., Zhang, H. L., Khor, I. W., Kaattari, I. M., and D. A. Shapiro.2002. Affinity maturation in trout: clonal dominance of high affinity antibodies late in the immune response. Developmental and Comparative Immunology. 26:191-200.
Ottinger, C. A., Lewis, T. D., Shapiro, D. A., Faisal, M., and S. L. Kaattari. 2001. Detection of Perkinsus marinus extracellular proteins in tissues of the Eastern oyster (Crassostrea virginica): Potential use in diagnostic assays. Journal of Aquatic Animal Health. 13:133-141.
Oliver, J. L., Gaffney, P. M., Allen, S. K. Jr., Faisal, M., and S. L. Kaattari. 2000. Protease inhibitory activity in the eastern oyster, Crassostrea virginica, and its relationship to disease resistance. Journal of Aquatic Animal Health. 12:136-145.
Ottinger, C. A., and S. L. Kaattari. 2000. Long-term immune dysfunction in rainbow trout (Oncorhynchus mykiss) exposed as embryos to aflatoxin B1. Fish and Shellfish Immunology. 10:101-106.
Kaattari, S. L., Klemer, J. V., and D. A. Evans. 1999. Teleost antibody structure: Simple prototype or elegant alternative? Bulletin of the European Society of Fish Pathologists.19:245-249.
Piganelli, J. D., G. D. Wiens, J. A. Zhang, J. M. Christensen and S. L. Kaattari. 1999. Evaluation of a whole cell, p57-vaccine against Renibacterium salmoninarum. Diseases of Aquatic Organisms 36:37 - 44.
Kaattari, S., Evans, D. and J. Klemer. 1998. Varied redox forms of teleost IgM: an alternative to isotypic diversity? Immunological Reviews166:133-142.
Evans, D. A., Klemer, J. V. and S. L. Kaattari. 1998. Heuristic models of the intermonomeric disulfide bonding process. Journal of Theoretical Biology 195: 505-524.
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Current Students
- Candace Spier
- Jianmin Ye
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Current Post-Docs
- Erin Bromage (James Cook University)
Courses
- MS 565: Principles of Pathobiology
- MS 567: Comparative Immunology
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Awards
- 2004 Special Achievement Award (American Fisheries Society)
- 2001 CSX Professor of Marine Science (Virginia Institute of Marine Science)
- 1993 James and Mildred Oldfield Team Award (Oregon State University)
- 1989 Oregon State University Service Award
- 1985 Finalist, Carter Award for Graduate Teaching in Science (OSU)
- 1983 Finalist, Carter Award for Undergraduate Teaching in Science (OSU)
Honor Societies
- Phi Kappa Phi
- Sigma Xi
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Professional Memberships
- American Association of Immunologists
- American Fisheries Society (Fish Health Section)
- American Society for Microbiology
- American Society for Cell Biology
- International Society for Developmental and Comparative Immunology
- Editorial Board: Fish and Shellfish Immunology
- Review Editor: Diseases of Aquatic Organisms
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Collaborative / Interdisciplinary Efforts
- National Fish Health Research Laboratory, Leetown, WV (USGS) Striped bass / mycobacteriosis studies
- University of Georgia Veterinary School and The National Center for Cool and Coldwater Aquaculture, Leetown, WV (USDA) Enhancement of humoral memory for aquacultural vaccines
- University of Rhode Island and USEPA: Fundulus heteroclitus immunotoxicology
- DiagXotics Inc. Consultant (Immunodiagnostics and vaccines for aquaculture)
- LUNA Inc.: Environmental applications for evascent wave technology
- Sapidyne Inc.: Analysis of antibody specificities and affinities using KinExA technology
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